Diagram of the HIV virus |
The Human Immunodeficiency Virus
commonly known as HIV in the last 30 years has become a worldwide epidemic
affecting approximately 23 million people with an additional 4 million cases
annually. This virus systematically
disrupts and destroys the host immune system and is the direct precursor to
Acquired Immunodeficiency Syndrome or AIDS.
Despite years of intense scientific research there is no cure or vaccine
for HIV. The current form of treatment
is continual use of anti-retroviral drugs which can help to keep HIV at bay but
are expensive and have side effects. The
virus itself invades a number of different immune cells and inserts its DNA
into the DNA of the cell causing it to produce more of the HIV virus. The virus itself is also toxic to subsets of
these cells known as CD4+ T cells which die after the virus has replicated
within the cell. The destruction of
these CD4+ T cells mediates the inability of the immune system to fight off
other pathogens.
Depiction of HIV spread from a DC to a T cell |
This
most recent paper is one small step towards finding a solution for HIV. While we are still a long way from developing
a cure, these papers help to implicate other sources for drug therapy. It also brings additional questions such as:
How do HIV buds spread across this immunological connection? Do the buds need to be in a certain proximity
to the CD4+ T cells? And, How do we
prevent this adhesion without blocking the normal necessary process of
adhesion? Only time will tell for these
questions but for now we are one step closer.
Paper:
1.
Evans, V. A., Kumar, N., Filali, A., Procopio,
F. A., Yegorov, O., Goulet, J. P., . . . Lewin, S. R. (2013). Myeloid dendritic
cells induce HIV-1 latency in non-proliferating CD4(+) T cells. PLoS
Pathogens, 9(12), e1003799.
Additional Sources:
1. Coleman, C. M., Gelais, C. S., & Wu, L. (2013). Cellular and viral mechanisms of HIV-1 transmission mediated by dendritic cells. Advances in Experimental Medicine and Biology, 762, 109-130
1. Coleman, C. M., Gelais, C. S., & Wu, L. (2013). Cellular and viral mechanisms of HIV-1 transmission mediated by dendritic cells. Advances in Experimental Medicine and Biology, 762, 109-130
2. Gopinath, A., Xu, G., Ress, D., Oktem, O., Subramaniam, S., & Bajaj, C. (2012). Shape-based regularization of electron tomographic reconstruction. IEEE Transactions on Medical Imaging, 31(12), 2241-2252. doi:10.1109/TMI.2012.2214229; 10.1109/TMI.2012.2214229
3. Pretorius, E., Oberholzer, H. M., Smit, E., Steyn, E., Briedenhann, S., & Franz, C. R. (2008). Ultrastructural changes in platelet aggregates of HIV patients: A scanning electron microscopy study. Ultrastructural Pathology, 32(3), 75-79. doi:10.1080/01913120802034793; 10.1080/01913120802034793
4. Steinman, R. M., & Inaba, K. (1999). Myeloid dendritic cells. Journal of Leukocyte Biology, 66(2), 205-208.
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