tag:blogger.com,1999:blog-717602462727821401.post5088597419081297818..comments2023-10-10T04:45:03.155-04:00Comments on Colgate Virology (and Immunology) Blog: IRF-1 is Essential for Immunity Against West Nile Virus Infection in MiceGeoffhttp://www.blogger.com/profile/07472521875173404609noreply@blogger.comBlogger1125tag:blogger.com,1999:blog-717602462727821401.post-15559555875380729152011-11-16T13:18:16.503-05:002011-11-16T13:18:16.503-05:00This is an interesting article, for obvious animal...This is an interesting article, for obvious animals lacking in IRF1 are susceptible to WNV, evidenced by the 0% survival rate in mice. <br /><br />The mechanisms behind this susceptibility were widely elaborated on, yet I do not believe the authors should have ignored the data on regulatory T cells simply because "mice that lack Tregs all together still displayed the T cells response irregularity". <br /><br />Regulatory T cells may still have some influence on the molecular signaling and the presence/absence of IFN gamma as well as other crucial signals that could be responsible for the proliferation of WNV. I would recommend extending research on that aspect to clarify the immune response against WNV and to further target factors that compromise its effectiveness.Allison Rabinowitzhttps://www.blogger.com/profile/15170754188589472045noreply@blogger.com